Diagnosis & Specialist Care of Allergy & Clinical Immunology - Since 1982
What Is Desensitisation Treatment?
Allergies occur when the immune system mistakenly identifies a harmless protein as a threat, triggering an overreaction and a release of histamine which leads to a range of symptoms. Airborne allergies typically trigger rhinitis symptoms, including:
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Itchy eyes, nose & throat
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Watery and red eyes
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Sneezing
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Congested feeling
Desensitisation treatment, also known as immunotherapy, is a proven method that works to build the immune system's tolerance to specific allergens by regularly exposing the body to concentrated doses of the allergen in question. Over time, the immune system gradually becomes less reactive, reducing or even eliminating allergic symptoms.

How allergies impact our life
Allergic rhinitis, the most common form of non-infectious rhinitis, affects approximately 10-15% of children and 26% of adults in the UK. Many of our patients have been struggling to avoid their allergy triggers for years, often relying on a combination of tablets, eye drops, and nasal sprays. However, despite their best efforts, debilitating symptoms can persist, impacting daily life, work, and even athletic performance.
From professional cyclists slowed down by a pollen allergy, or office workers unable to concentrate due to constant itching, sneezing, and fatigue. While antihistamines offer relief for many, others can find them difficult to tolerate, and sometimes even high doses may not fully control the symptoms.
The Benefits of Immunotherapy
When antihistamines are not enough, immunotherapy offers a more definitive solution. This treatment is particularly effective for airborne allergens, including pollens, dust mites, moulds, and animal dander. It has been shown to significantly reduce symptoms in the majority of patients, as well as a reduced reliance on medication.​
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The treatment we offer in clinic is known as sublingual immunotherapy (SLIT) as it is taken in the form of tablets or oral drops placed under the tongue​
Sublingual Immunotherapy (SLIT):
Background:
A more modern approach to immunotherapy, first proposed in 1986
Medication Type:
An oral drop or small tablet under the tongue
Dose:
Once daily, usually for a period of three years.
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Other Information::
The first dose is administered under medical supervision and, provided it is well tolerated, the rest of the treatment can be conveniently continued at home.
Immunotherapy also exists as a subcutaneous injection, although this is not offered in our clinic as the sublingual route is generally considered to be safer whilst being equally as effective.
Pre-seasonal treatment
For seasonal allergies such as hay fever, immunotherapy should be started 2-3 months before the pollen season begins. This is to ensure maximal efficacy and also reduce the likelihood of difficult side effects.
For perennial allergens, such as house dust mites, treatment can be started at any time of year.
